Guerrios-Rivera Lourdes, Howard Lauren, Frank Jennifer, De Hoedt Amanda, Beverly Devon, Grant Delores J, Hoyo Cathrine, Freedland Stephen J
Urology Section, Surgery Department, Veterans Administration Caribbean Healthcare System and University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC; Urology Section, Veterans Affairs Medical Center Durham, Durham, NC.
Urology. 2017 Jul;105:129-135. doi: 10.1016/j.urology.2017.03.042. Epub 2017 Apr 10.
To test multiple adiposity measures and prostate cancer (PC) risk in men undergoing prostate biopsy. We hypothesized that body mass index (BMI), body fat, and waist circumference would be highly correlated, and all would be associated with aggressive PC, but not overall risk.
A case (483)-control (496) study among men undergoing prostate biopsy from 2007 to 2016 was conducted at the Durham Veterans Affairs Medical Center. Anthropometric and self-reported measurements were taken. Percent body fat was measured. Associations between adiposity measures and PC risk and high-grade PC (Gleason ≥7) were examined using logistic regression.
BMI, percent body fat, and waist circumference were highly correlated (ρ ≥ .79) (P < .001). On multivariable analysis, BMI (P = .011) was associated with overall PC risk, but percent body fat (P = .16) and waist circumference (P = .19) were not. However, all adiposity measurements were associated with high-grade disease (P < .001). We found a strong relationship between self-reported and measured weight (ρ = .97) and height (ρ = .92).
BMI, body fat, and waist circumference were all highly correlated and associated with aggressive PC. This study supports the idea that higher adiposity is selectively associated with high-grade PC and reinforces the continued use of self-reported BMI as a measure of obesity in epidemiologic studies of PC.
在接受前列腺活检的男性中测试多种肥胖指标与前列腺癌（PC）风险的关系。我们假设体重指数（BMI）、体脂和腰围会高度相关，并且所有这些指标都与侵袭性前列腺癌相关，但与总体风险无关。
2007年至2016年期间，在达勒姆退伍军人事务医疗中心对接受前列腺活检的男性进行了一项病例（483例）对照（496例）研究。进行了人体测量和自我报告的测量。测量了体脂百分比。使用逻辑回归分析肥胖指标与前列腺癌风险以及高级别前列腺癌（Gleason评分≥7）之间的关联。
BMI、体脂百分比和腰围高度相关（ρ≥0.79）（P<0.001）。多变量分析显示，BMI（P=0.011）与总体前列腺癌风险相关，但体脂百分比（P=0.16）和腰围（P=0.19）与总体前列腺癌风险无关。然而，所有肥胖测量指标均与高级别疾病相关（P<0.001）。我们发现自我报告的体重与测量体重之间（ρ=0.97）以及身高与测量身高之间（ρ=0.92）存在很强的相关性。
BMI、体脂和腰围均高度相关且与侵袭性前列腺癌相关。本研究支持较高肥胖程度与高级别前列腺癌选择性相关的观点，并强化了在前列腺癌流行病学研究中继续使用自我报告的BMI作为肥胖衡量指标的做法。
