Ward P A, Cunningham T W, Walker B A, Johnson K J
University of Michigan Medical School, Department of Pathology, Ann Arbor 48109.
Biochem Biophys Res Commun. 1988 Jul 29;154(2):746-51. doi: 10.1016/0006-291x(88)90203-3.
In formyl peptide stimulated human neutrophils the enhancement of O2.- responses by ATP and ATP S requires extracellular calcium. In contrast, the inhibitory effects of adenosine are independent of a calcium requirement. Rates of O2.- generation are not affected by these adenine compounds. Rather, ATP and ATP S cause a sustained period of generation whereas adenosine causes an abrupt early termination of the O2- response. The differing calcium requirements for regulatory effects of adenine compounds on O2.- responses of stimulated neutrophils suggests that ATP (or ATP gamma S) and adenosine may exert their effects at different points in the pathway of signal transduction events.
在甲酰肽刺激的人中性粒细胞中，ATP和ATPγS对超氧阴离子（O2.-）反应的增强作用需要细胞外钙。相比之下，腺苷的抑制作用与钙需求无关。超氧阴离子的生成速率不受这些嘌呤化合物的影响。相反，ATP和ATPγS会导致一段持续的生成期，而腺苷会导致超氧阴离子反应提前突然终止。嘌呤化合物对刺激的中性粒细胞超氧阴离子反应的调节作用对钙的需求不同，这表明ATP（或ATPγS）和腺苷可能在信号转导事件途径的不同点发挥作用。
