Saint-André J P, Chapeau M C, Pein F
Laboratoire d'Anatomie Pathologique, CHU, Angers.
Ann Pathol. 1988;8(2):144-8.
We report the anatomoclinical analysis of a child with a renal tumor: the preoperative diagnosis was neuroblastoma, because of elevated dopamine urinary excretion and positive MIBG scintigraphy. The histopathological and immunohistochemical analysis revealed a prominent neural differentiation in a multicystic nephroblastoma. This observation recalls the Masson's proposed neuroectodermal histogenesis of Wilms tumor; however the currently accepted metanephrogenic blastematous origin is not reconsidered. This is the first case of nephroblastoma with a neural differentiation detectable otherwise from by pathological analysis.
术前诊断为神经母细胞瘤，原因是尿多巴胺排泄升高且MIBG闪烁扫描呈阳性。组织病理学和免疫组织化学分析显示，多房性肾母细胞瘤存在显著的神经分化。这一观察结果使人想起马森提出的肾母细胞瘤神经外胚层组织发生学说；然而，目前公认的后肾胚基起源并未被重新考虑。这是首例通过病理分析可检测到神经分化的肾母细胞瘤病例。
