Kaneko M, Sato M, Ogasawara K, Imamura T, Hashimoto K, Momoi N, Hosoya M
J Neonatal Perinatal Med. 2017;10(2):147-155. doi: 10.3233/NPM-171669.
To investigate the relationships between serum cytokine concentrations and chorioamnionitis (CAM) and CAM-related bronchopulmonary dysplasia (BPD) in premature infants.
Serum was collected at 0 and 7 days after birth from 36 premature infants born at <32 weeks of gestation. We examined the relationships between 30 cytokine concentrations and CAM, BPD, and other perinatal factors.
On day 0, GM-CSF, IL-15, IL-17, IL-2, IL-2R, VEGF, and MIG concentrations were significantly higher in the CAM group (n = 17) than in the non-CAM group (n = 19). These concentrations had decreased by day 7 and were similar in both groups. The IL-12p70 concentration on day 0 was significantly lower in the BPD group (n = 16) than in the non-BPD group (n = 15). BPD incidence was similar between the CAM and non-CAM groups.
These data support the hypothesis that intrauterine inflammation is not a primary risk factor for BPD. The immunological environment at birth or soon after, rather than intrauterine fetal inflammation (e.g., CAM), is a primary risk factor for BPD onset in preterm infants. Decreased inflammatory responses are particularly relevant, as indicated by the relationship between BPD and low serum IL-12p70 concentrations on day 0.
探讨早产儿血清细胞因子浓度与绒毛膜羊膜炎（CAM）及CAM相关支气管肺发育不良（BPD）之间的关系。
收集36例孕周<32周的早产儿出生后0天和7天的血清。我们检测了30种细胞因子浓度与CAM、BPD及其他围产期因素之间的关系。
出生后0天，CAM组（n = 17）的粒细胞巨噬细胞集落刺激因子（GM-CSF）、白细胞介素15（IL-15）、白细胞介素17（IL-17）、白细胞介素2（IL-2）、白细胞介素2受体（IL-2R）、血管内皮生长因子（VEGF）和巨噬细胞炎性蛋白-1γ（MIG）浓度显著高于非CAM组（n = 19）。这些浓度在第7天时下降，两组相似。BPD组（n = 16）出生后0天的白细胞介素12p70浓度显著低于非BPD组（n = 15）。CAM组和非CAM组的BPD发病率相似。
这些数据支持以下假说，即宫内炎症不是BPD的主要危险因素。出生时或出生后不久的免疫环境，而非宫内胎儿炎症（如CAM），是早产儿发生BPD的主要危险因素。如BPD与出生后0天低血清白细胞介素12p70浓度之间的关系所示，炎症反应降低尤为重要。
