Heuser I, von Bardeleben U, Boll E, Holsboer F
Department of Psychiatry, University of Mainz, West Germany.
Biol Psychiatry. 1988 Jul;24(3):316-21. doi: 10.1016/0006-3223(88)90200-4.
The authors administered 100 micrograms human corticotropin-releasing hormone (h-CRH) to alcohol-dependent subjects after short-term abstention from alcohol abuse and observed that these patients released significantly less adrenocorticotrophic hormone (ACTH) than a control group. Cortisol responses were also blunted, but this effect was less pronounced. These findings indicate that hypercortisolism in alcohol withdrawal is driven by a central neurotransmitter/receptor disturbance rather than by peripheral alterations.
作者在酒精依赖受试者短期戒酒之后给予其100微克人促肾上腺皮质激素释放激素（h-CRH），并观察到这些患者释放的促肾上腺皮质激素（ACTH）明显少于对照组。皮质醇反应也减弱，但这种效应不太明显。这些发现表明，酒精戒断期间的高皮质醇血症是由中枢神经递质/受体紊乱而非外周改变所驱动的。
