Fadel Cicely W, Colson Eve R, Corwin Michael J, Rybin Denis, Heeren Timothy C, Wang Colin, Moon Rachel Y
Division of General Pediatrics and Community Health, Children's National Health System, Washington, DC.
Department of Pediatrics, Yale University, New Haven, CT.
J Pediatr. 2017 Jun;185:136-142.e1. doi: 10.1016/j.jpeds.2017.02.012. Epub 2017 Mar 3.
To assess the role of maternal attitudes and other factors associated with infant vaccination status.
Data on reported vaccination status were analyzed from a nationally representative prospective survey of mothers of 2- to 6-month-old infants. Weighted univariate and multiple logistic regression analyses were conducted. Latent profile analysis of mothers reporting nonimmunized infants identified distinct groups, RESULTS: Of 3268 mothers, 2820 (weighted 86.2%), 311 (9.1%), and 137 (4.7%), respectively, reported their infant had received all, some, or no recommended vaccinations for age. Younger infants and infants with younger mothers were more likely to have received no vaccinations. Mothers with neutral and negative attitudes toward vaccination were >3 (aOR 3.66, 95% CI 1.80-7.46) and 43 times (aOR 43.23, 95% CI 20.28-92.16), respectively, more likely than mothers with positive attitudes to report their infants had received no vaccinations. Two subgroups of mothers reporting that their infants had received no vaccinations were identified: group A (52.5%) had less than positive attitudes and less than positive subjective norms about vaccination (ie, perceived social pressure from others); group B (47.5%) had positive attitudes and positive subjective norms. Group A mothers were more likely to be white (76.1% vs 48.3%, P?=?.002), more educated (43.5% vs 35.4% college or higher, P?=?.02), and to exclusively breastfeed (74.9% vs. 27.3%, P?<?.001).
Although access barriers can result in nonvaccination, less than positive maternal attitude toward vaccination was the strongest predictor. Strategies to improve vaccination rates must focus on both improved access and better understanding of factors underlying maternal attitudes.
评估母亲态度及其他与婴儿疫苗接种状况相关因素的作用。
对全国具有代表性的2至6个月大婴儿母亲的前瞻性调查中报告的疫苗接种状况数据进行分析。进行加权单因素和多因素逻辑回归分析。对报告婴儿未接种疫苗的母亲进行潜在类别分析,以确定不同组别。
在3268名母亲中,分别有2820名(加权后为86.2%)、311名(9.1%)和137名(4.7%)报告其婴儿已接种所有、部分或未接种该年龄段推荐的全部疫苗。年龄较小的婴儿以及母亲年龄较小的婴儿更有可能未接种疫苗。对疫苗接种持中立和消极态度的母亲报告其婴儿未接种疫苗的可能性分别比持积极态度的母亲高3倍(调整后比值比[aOR] 3.66,95%置信区间[CI] 1.80 - 7.46)和43倍(aOR 43.23,95% CI 20.28 - 92.16)。确定了两组报告婴儿未接种疫苗的母亲亚组:A组(52.5%)对疫苗接种的态度和主观规范不太积极(即感受到他人的社会压力);B组(47.5%)态度积极且主观规范积极。A组母亲更有可能是白人(76.1%对48.3%,P = 0.002),受教育程度更高(43.5%对35.4%为大学及以上学历,P = 0.02),且纯母乳喂养比例更高(74.9%对27.3%,P < 0.001)。
尽管获取疫苗存在障碍可能导致未接种疫苗,但母亲对疫苗接种不太积极的态度是最强的预测因素。提高疫苗接种率的策略必须既注重改善获取疫苗的机会,又要更好地理解影响母亲态度的潜在因素。