生物医学背景下的真菌免疫调节蛋白

Fungal immunomodulatory proteins in the context of biomedicine.

作者信息

Uribe-Echeverry Paula Tatiana, Lopez-Gartner German Ariel

机构信息

Health Faculty, University of Manizales, Street 9a # 19-03, Manizales, Colombia.

Department, Natural Sciences Faculty, University of Caldas, Street 65 # 26-10, Manizales, Colombia,

出版信息

Front Biosci (Elite Ed). 2017 Jun 1;9(2):286-306. doi: 10.2741/e803.

DOI:10.2741/e803

PMID:28410152

Abstract

Fungi represent a large group of biodiverse microorganisms with potential applications ranging from industrial fields to the treatment for human diseases. A large number of pharmacologically active compounds including terpenoids, polysaccharides and proteins have been derived from these microorganisms. Fungal Immunomodulatory Proteins (FIPs) are a group of active compounds that are being considered for the treatment of asthma, allergy, autoimmune diseases and cancer. Here, we discuss the discovery, heterologous production bioactive mechanisms of action and their potential use in biomedicine.

摘要

真菌是一大类具有生物多样性的微生物，其潜在应用范围从工业领域到人类疾病治疗。从这些微生物中已衍生出大量具有药理活性的化合物，包括萜类化合物、多糖和蛋白质。真菌免疫调节蛋白（FIPs）是一类正在被考虑用于治疗哮喘、过敏、自身免疫性疾病和癌症的活性化合物。在此，我们讨论它们的发现、异源生产、生物活性作用机制及其在生物医学中的潜在用途。