Nguyen Kevin A, Syed Jamil S, Shuch Brian
Department of Urology, Yale School of Medicine, 789 Howard Avenue, New Haven, CT 06520, USA.
Department of Radiology, Yale School of Medicine, PO Box 208058, New Haven, CT 06520-8058, USA; Department of Urology, Yale School of Medicine, PO Box 208058, New Haven, CT 06520-8058, USA.
Urol Clin North Am. 2017 May;44(2):155-167. doi: 10.1016/j.ucl.2016.12.002. Epub 2017 Mar 14.
The management of patients with hereditary kidney cancers presents unique challenges to clinicians. In addition to an earlier age of onset compared with patients with sporadic kidney cancer, those with hereditary kidney cancer syndromes often present with bilateral and/or multifocal renal tumors and are at risk for multiple de novo lesions. This population of patients may also present with extrarenal manifestations, which adds an additional layer of complexity. Physicians who manage these patients should be familiar with the underlying clinical characteristics of each hereditary kidney cancer syndrome and the suggested surgical approaches and recommendations of genetic testing for at-risk individuals.
遗传性肾癌患者的管理给临床医生带来了独特的挑战。与散发性肾癌患者相比，遗传性肾癌患者不仅发病年龄更早，而且患有遗传性肾癌综合征的患者通常表现为双侧和/或多灶性肾肿瘤，并有发生多个新发病变的风险。这类患者还可能出现肾外表现，这增加了一层复杂性。治疗这些患者的医生应熟悉每种遗传性肾癌综合征的潜在临床特征，以及针对高危个体的建议手术方法和基因检测建议。
