Born Willi K, Huang Yafei, Reinhardt R Lee, Huang Hua, Sun Deming, O'Brien Rebecca L
National Jewish Health, Denver, CO, United States; University of Colorado Health Sciences Center, Aurora, CO, United States.
Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; Joint Laboratory for Stem Cell Engineering and Technology Transfer, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Adv Immunol. 2017;134:1-45. doi: 10.1016/bs.ai.2017.01.002. Epub 2017 Feb 14.
γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition. Functionally, γδ T cells represent a system of differentiated subsets, sometimes engaged in cross-regulation, which ultimately determines their effect on other components of the immune system, including B cells and antibodies. γδ T cells are capable of providing help to B cells in antibody production. More recently it became clear that γδ T cells influence B cell differentiation during the peripheral stages of B cell development, control levels of circulating immunoglobulin (all subclasses), and affect production of autoantibodies. Because of this relationship between γδ T cells and B cells, the extensive variation of γδ T cells among human individuals might be expected to modulate their humoral responsiveness.
γδ T细胞是有颌脊椎动物三方适应性免疫系统的第三部分，另外两部分是αβ T细胞和B细胞。与其他两种淋巴细胞类型一样，它们表达多种抗原受体，能够特异性识别配体。在功能上，γδ T细胞代表一个分化亚群系统，有时参与交叉调节，最终决定它们对免疫系统其他成分（包括B细胞和抗体）的影响。γδ T细胞能够在抗体产生过程中为B细胞提供帮助。最近人们清楚地认识到，γδ T细胞在B细胞发育的外周阶段影响B细胞分化，控制循环免疫球蛋白（所有亚类）的水平，并影响自身抗体的产生。由于γδ T细胞和B细胞之间的这种关系，人们可能预期人类个体中γδ T细胞的广泛变异会调节其体液反应性。
