精神病中认知洞察力的代谢基础：一项正电子发射断层扫描研究。
The metabolic basis of cognitive insight in psychosis: A positron emission tomography study.
作者信息
Caletti Elisabetta, Marotta Giorgio, Del Vecchio Giuseppe, Paoli Riccardo A, Cigliobianco Michela, Prunas Cecilia, Zugno Elisa, Bottinelli Francesca, Brambilla Paolo, Altamura A Carlo
机构信息
Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Section of Nuclear Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
出版信息
PLoS One. 2017 Apr 17;12(4):e0175803. doi: 10.1371/journal.pone.0175803. eCollection 2017.
UNLABELLED
The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping.
RESULTS
patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.
未标注
本研究旨在调查精神病患者认知洞察力与脑代谢之间的关系。对63例接受正电子发射断层扫描检查的精神病患者进行了贝克认知洞察力量表（BCIS）测试。根据BCIS评分将样本分为两组。使用统计参数映射分析数据。
结果
与高洞察力患者相比，低洞察力患者双侧右侧梭状回、左侧楔前叶、颞上回和脑岛代谢降低，左侧眶额回代谢增加（所有p<0.005）。我们的结果表明，后部（枕颞岛顶叶）脑代谢降低和前部（眶额）脑代谢增加可能维持精神病患者的低认知洞察力。
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