患白血病双胞胎的不同病程。

Dissimilar courses of twins with leukemia.

作者信息

Stewart S J, Shepherd D A, Steuber C P, Starling K A, Falletta J M

出版信息

Med Pediatr Oncol. 1977;3(3):231-5. doi: 10.1002/mpo.2950030303.

Abstract

Twin girls, genetically identical, probably experienced different leukemogenic events and presented with acute lymphocytic leukemia 6 years apart. Their clinical presentations were similar, but they received significantly different therapy. The first twin died 34 months after diagnosis following multiple remissions and relapses, having received single-drug maintenance. The second twin remains free of apparent disease 60 months after diagnosis, following vincristine and prednisone induction, 6-mercaptopurine maintenance, methotrexate and prednisone reinforcement, and central nervous system treatment of occult disease. Their dissimilar clinical courses may have been due to different leukemogenic events and/or markedly different therapeutic programs.

摘要

一对同卵双胞胎女孩，可能经历了不同的致白血病事件，分别在相隔6年时患上急性淋巴细胞白血病。她们的临床表现相似，但接受的治疗却显著不同。第一个双胞胎在诊断后34个月死亡，经历了多次缓解和复发，接受的是单药维持治疗。第二个双胞胎在诊断后60个月仍无明显疾病，接受了长春新碱和泼尼松诱导治疗、6-巯基嘌呤维持治疗、甲氨蝶呤和泼尼松强化治疗以及隐匿性疾病的中枢神经系统治疗。她们不同的临床病程可能是由于不同的致白血病事件和/或明显不同的治疗方案。