Donato Rosario, Sorci Guglielmo, Giambanco Ileana
Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica Funzionale, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132, Perugia, Italy.
Department of Experimental Medicine, Istituto Interuniversitario di Miologia (Interuniversity Institute for Myology), Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132, Perugia, Italy.
Cell Mol Life Sci. 2017 Aug;74(15):2749-2760. doi: 10.1007/s00018-017-2526-9. Epub 2017 Apr 17.
S100A6 protein belongs to the A group of the S100 protein family of Ca-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6's effects. Dosage of serum S100A6 might aid in diagnosis in oncology.
S100A6蛋白属于钙结合蛋白S100蛋白家族的A组。它在成年正常组织中的有限数量细胞类型以及几种肿瘤细胞类型中表达。作为一种细胞内蛋白,S100A6参与了多种细胞功能的调节,如增殖、凋亡、细胞骨架动力学以及细胞对不同应激因子的反应。S100A6可被某些细胞类型分泌/释放,这表明该蛋白具有细胞外效应。晚期糖基化终产物受体(RAGE)和整合素β1可传导细胞外S100A6的一些效应。血清S100A6的检测量可能有助于肿瘤学诊断。