[中枢胆碱能突触的药理学]
[Pharmacology of central cholinergic synapse].
作者信息
Decombe R, Bentué-Ferrer D, Van den Driessche J, Allain H
机构信息
Laboratoire de pharmacologie, Université de Rennes.
出版信息
Rev Med Interne. 1988 May-Jun;9(3):314-20. doi: 10.1016/s0248-8663(88)80102-4.
Because it intervenes in normal and pathological cerebral ageing, plays a role in late dyskinesias of Parkinson's syndrome and is involved in the memorization processes, central cholinergic neurotransmission deserves to be known with precision. Its physiological approach deals with the anatomical organization of the central cholinergic system and with the mechanisms of synthesis, release and degradation of acetylcholine and its interaction with its receptors. The pharmacological changes (inhibition or stimulation) conceivable at different levels lead to therapeutic applications.
由于它干预正常和病理性脑老化，在帕金森综合征的迟发性运动障碍中起作用，并参与记忆过程，中枢胆碱能神经传递值得精确了解。其生理学方法涉及中枢胆碱能系统的解剖组织以及乙酰胆碱的合成、释放和降解机制及其与受体的相互作用。在不同水平上可能出现的药理学变化（抑制或刺激）导致了治疗应用。
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