Harron Katie, Gilbert Ruth, Cromwell David, Oddie Sam, van der Meulen Jan
Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
UCL Great Ormond Street Institute of Child Health, London, UK.
Paediatr Perinat Epidemiol. 2017 May;31(3):221-232. doi: 10.1111/ppe.12359. Epub 2017 Apr 18.
Evidence on the association between newborn length of hospital stay (LOS) and risk of readmission is conflicting. We compared methods for modelling this relationship, by gestational age, using population-level hospital data on births in England between 2005-14.
The association between LOS and unplanned readmission within 30 days of postnatal discharge was explored using four approaches: (i) modelling hospital-level LOS and readmission rates; (ii) comparing trends over time in LOS and readmission; (iii) modelling individual LOS and adjusted risk of readmission; and (iv) instrumental variable analyses (hospital-level mean LOS and number of births on the same day).
Of 4 667 827 babies, 5.2% were readmitted within 30 days. Aggregated data showed hospitals with longer mean LOS were not associated with lower readmission rates for vaginal (adjusted risk ratio (aRR) 0.87, 95% confidence interval (CI) 0.66, 1.13), or caesarean (aRR 0.89, 95% CI 0.72, 1.12) births. LOS fell by an average 2.0% per year for vaginal births and 3.4% for caesarean births, while readmission rates increased by 4.4 and 5.1% per year respectively. Approaches (iii) and (iv) indicated that longer LOS was associated with a reduced risk of readmission, but only for late preterm, vaginal births (34-36 completed weeks' gestation).
Longer newborn LOS may benefit late preterm babies, possibly due to increased medical or psychosocial support for those at greater risk of potentially preventable readmissions after birth. Research based on observational data to evaluate relationships between LOS and readmission should use methods to reduce the impact of unmeasured confounding.
关于新生儿住院时长(LOS)与再入院风险之间关联的证据相互矛盾。我们利用2005年至2014年间英格兰出生人口的全人群层面医院数据,按胎龄比较了对此种关系进行建模的方法。
采用四种方法探讨住院时长与产后出院30天内非计划再入院之间的关联:(i)对医院层面的住院时长和再入院率进行建模;(ii)比较住院时长和再入院随时间的趋势;(iii)对个体住院时长和调整后的再入院风险进行建模;以及(iv)工具变量分析(医院层面的平均住院时长和同日出生人数)。
在4,667,827名婴儿中,5.2%在30天内再次入院。汇总数据显示,平均住院时长较长的医院,其阴道分娩(调整风险比(aRR)0.87,95%置信区间(CI)0.66,1.13)或剖宫产(aRR 0.89,95% CI 0.72,1.12)的再入院率并未降低。阴道分娩的住院时长平均每年下降2.0%,剖宫产下降3.4%,而再入院率分别每年上升4.4%和5.1%。方法(iii)和(iv)表明,较长的住院时长与再入院风险降低相关,但仅适用于晚期早产阴道分娩(妊娠34 - 36整周)。
较长的新生儿住院时长可能对晚期早产婴儿有益,这可能是因为对出生后有潜在可预防再入院较高风险的婴儿增加了医疗或心理社会支持。基于观察性数据评估住院时长与再入院之间关系的研究应采用方法以减少未测量混杂因素的影响。