Xin Y Y, Ming Z G, Peng G Y, Jian A, Min L H
National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People's Republic of China.
Am J Trop Med Hyg. 1988 Aug;39(2):214-7. doi: 10.4269/ajtmh.1988.39.214.
In a study begun in 1985, 1,026 children between the ages of 5 and 12 years, living in an area of low Japanese encephalitis (JE) infection, were vaccinated with live-attenuated JE vaccine, strain SA14-14-2. A group of 47 of the vaccinated children, 5-6 years of age, were examined for fever and other systemic reactions every other day for 2 weeks following vaccination. None of these children had temperatures greater than 37.4 degrees C or other systemic reactions during the observation period. No untoward reactions were reported in the remainder of the vaccinated group. After immunization, seroconversion rates in seronegative children were 100% (GMT 35.3, n = 11), 100% (GMT 31.7, n = 12), and 83.3% (GMT 23, n = 10) in groups receiving vaccine diluted 1:3, 1:5, and 1:50, respectively. These results indicate that the JE SA14-14-2 live-attenuated vaccine is immunogenic and safe for children.
在一项始于1985年的研究中，对居住在日本脑炎（JE）低感染地区的1026名5至12岁儿童接种了减毒活JE疫苗SA14 - 14 - 2株。对47名5至6岁的接种儿童在接种后每隔一天进行为期2周的发热及其他全身反应检查。在观察期内，这些儿童均无体温高于37.4摄氏度或其他全身反应。接种组的其余儿童未报告有不良反应。免疫后，分别接受1:3、1:5和1:50稀释疫苗组的血清阴性儿童的血清转化率分别为100%（几何平均滴度[GMT] 35.3，n = 11）、100%（GMT 31.7，n = 12）和83.3%（GMT 23，n = 10）。这些结果表明，JE SA14 - 14 - 2减毒活疫苗对儿童具有免疫原性且安全。
