短文：HIV与丙型肝炎病毒合并感染患者的愤怒情绪与生活质量：一项横断面研究（ANRS CO13-HEPAVIH）

Short article: Anger and quality of life in patients co-infected with HIV and hepatitis C virus: a cross-sectional study (ANRS CO13-HEPAVIH).

作者信息

Marcellin Fabienne, Protopopescu Camelia, Esterle Laure, Wittkop Linda, Piroth Lionel, Aumaitre Hugues, Bouchaud Olivier, Goujard Cécile, Vittecoq Daniel, Dabis François, Salmon-Ceron Dominique, Spire Bruno, Roux Perrine, Carrieri Maria P

机构信息

aAix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale bORS PACA, Observatoire régional de la santé Provence-Alpes-Côte d'Azur, Marseille cUniversity of Bordeaux, ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401 dCHU de Bordeaux, Pole de sante publique, Bordeaux eDépartement d'Infectiologie, Centre Hospitalier Universitaire de Dijon Université de Bourgogne, Dijon fService Maladies infectieuses et tropicales, Centre Hospitalier de Perpignan, Perpignan gService Maladies infectieuses et tropicales, AP-HP, Hôpital Avicenne hUniversité Paris 13 Nord, Bobigny iService Médecine interne et Immunologie clinique, AP-HP, Hôpital Bicêtre, Hôpitaux universitaires Paris Sud jUniversité Paris Sud kService Maladies infectieuses et tropicales, AP-HP, Hôpital Bicêtre, Hôpitaux universitaires Paris Sud, Le Kremlin-Bicêtre lUniversité Paris Descartes mService Maladies infectieuses et tropicales, AP-HP, Hôpital Cochin, Paris, France.

出版信息

Eur J Gastroenterol Hepatol. 2017 Jul;29(7):786-791. doi: 10.1097/MEG.0000000000000883.

DOI:10.1097/MEG.0000000000000883

PMID:28418984

Abstract

OBJECTIVE

The aim of this study is to document the relationship between anger dimensions (state, trait, expression, and control) and quality of life (QoL) in patients co-infected with HIV and hepatitis C virus (HCV).

PATIENTS AND METHODS

This is a cross-sectional study nested in the ANRS CO13-HEPAVIH French national cohort. Anger and QoL were assessed using self-administered questionnaires in 536 HIV-HCV-co-infected patients. Correlations between anger scores (STAXI-2 scale) and QoL scores (WHOQOL-HIV BREF scale) were assessed using Spearman's coefficients. Multiple linear regression models were then used to test the relationship between the different dimensions of anger and QoL after adjustment for statistically significant psychosocial, sociobehavioral, and clinical characteristics.

RESULTS

Patients with excessive alcohol use or history of injecting drug use had higher levels of anger. All dimensions of anger were significantly correlated with impaired QoL for all six dimensions of the WHOQOL-HIV BREF scale. Greater internal experience of anger and impaired anger control were confirmed as independent correlates of impaired QoL related to psychological health, social relationships, and patients' beliefs after adjustment for depressive symptoms, functional impact of fatigue, socioeconomic status, and HIV-related characteristics.

CONCLUSION

Anger issues need close monitoring in HIV-HCV-co-infected patients, especially in patients with addictive behaviors. Screening for problems in anger management and implementing individualized psychotherapeutic strategies may help improve QoL in this population.

摘要

目的

本研究旨在记录同时感染人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）的患者的愤怒维度（状态、特质、表达和控制）与生活质量（QoL）之间的关系。

患者与方法

这是一项嵌套于法国国家ANRS CO13-HEPAVIH队列中的横断面研究。使用自填式问卷对536例HIV-HCV合并感染患者的愤怒和生活质量进行评估。使用Spearman系数评估愤怒得分（STAXI-2量表）与生活质量得分（WHOQOL-HIV BREF量表）之间的相关性。然后使用多元线性回归模型，在对具有统计学意义的心理社会、社会行为和临床特征进行调整后，检验愤怒的不同维度与生活质量之间的关系。

结果

有过量饮酒或注射吸毒史的患者愤怒水平更高。愤怒的所有维度与WHOQOL-HIV BREF量表的所有六个维度的生活质量受损均显著相关。在对抑郁症状、疲劳的功能影响、社会经济地位和HIV相关特征进行调整后，愤怒的更多内在体验和愤怒控制受损被确认为与心理健康、社会关系和患者信念相关的生活质量受损的独立相关因素。