Vilidaite Greta, Yu Miaomiao, Baker Daniel H
Department of Psychology, University of York, York, North Yorkshire, YO10 5DD, United Kingdom.
Autism Res. 2017 Aug;10(8):1384-1391. doi: 10.1002/aur.1781. Epub 2017 Apr 17.
Previous neuroimaging research has reported increased internal (neural) noise in sensory systems of autistic individuals. However, it is unclear if this difference has behavioural or perceptual consequences, as previous attempts at measuring internal noise in ASD psychophysically have been indirect. Here, we use a "gold standard" psychophysical double-pass paradigm to investigate the relationship between internal noise and autistic traits in the neurotypical population (n = 43). We measured internal noise in three tasks (contrast perception, facial expression intensity perception, and number summation) to estimate a global internal noise factor using principal components analysis. This global internal noise was positively correlated with autistic traits (r = 0.32, P = 0.035). This suggests that increased internal noise is associated with the ASD phenotype even in subclinical populations. The finding is discussed in relation to the neural and genetic basis of internal noise in ASD. Autism Res 2017, 10: 1384-1391. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
先前的神经影像学研究报告称，自闭症个体的感觉系统中内部（神经）噪声增加。然而，目前尚不清楚这种差异是否会产生行为或感知方面的后果，因为之前在自闭症谱系障碍（ASD）中通过心理物理学方法测量内部噪声的尝试都是间接的。在此，我们使用一种“金标准”心理物理学双通范式，来研究神经典型人群（n = 43）中内部噪声与自闭症特征之间的关系。我们在三项任务（对比度感知、面部表情强度感知和数字求和）中测量了内部噪声，并使用主成分分析来估计一个全局内部噪声因子。这个全局内部噪声与自闭症特征呈正相关（r = 0.32，P = 0.035）。这表明，即使在亚临床人群中，内部噪声增加也与ASD表型相关。我们将结合ASD中内部噪声的神经和遗传基础来讨论这一发现。《自闭症研究》2017年，10: 1384 - 1391。© 2017国际自闭症研究协会，威利期刊公司
