自闭症谱系障碍患者在言语产生过程中神经活动的个体内变异性增加。
Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.
作者信息
Heller Murray Elizabeth S, Segawa Jennifer, Karahanoglu F Isik, Tocci Catherine, Tourville Jason A, Nieto-Castanon Alfonso, Tager-Flusberg Helen, Manoach Dara S, Guenther Frank H
机构信息
Boston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215.
Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, 55 Fruit Street, Boston, MA, 02215.
出版信息
Res Autism Spectr Disord. 2022 Jun;94. doi: 10.1016/j.rasd.2022.101955. Epub 2022 Apr 7.
BACKGROUND
Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task.
METHODS
Neural activities of participants with ASD (N = 15, = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm.
RESULTS
There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech.
CONCLUSIONS
These findings highlight the importance of understanding intra-subject neural variability in participants with ASD.
背景
沟通困难是许多自闭症谱系障碍（ASD）患者的核心缺陷。本研究评估了ASD患者和神经典型（NT）对照者在言语产生任务期间的神经激活情况。
方法
使用功能磁共振成像和稀疏采样范式检查了ASD患者（N = 15，平均年龄 = 16.7岁，语言能力从低语言能力到语言流畅）和NT对照者（N = 12，平均年龄 = 17.1岁）的神经活动。
结果
ASD组和NT组在平均言语激活或言语激活的受试者间逐次运行变异性方面没有差异。ASD组的受试者内逐次神经变异性更大，并且与与言语相关的皮质区域的自闭症严重程度呈正相关。
结论
这些发现凸显了了解ASD患者受试者内神经变异性的重要性。
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