Dyer R G, Grossmann R, Mansfield S, Diez-Guerra F J, Bicknell R J, Hollingsworth S
Department of Neuroendocrinology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
Brain Res Bull. 1988 Jun;20(6):721-7. doi: 10.1016/0361-9230(88)90083-4.
A series of experiments are described which show (a) that the release of noradrenaline in the preoptic area of rats is regulated by a presynaptic opioid receptor and, (b) that changes in the opioid control of preoptic noradrenaline release are associated with the anovulatory condition found in adult female rats which have been exposed to androgen neonatally. The experiments support the hypothesis that opioid-noradrenergic interaction in the preoptic area is an important component in the neural mechanism regulating gonadotrophin secretion.
本文描述了一系列实验，这些实验表明：（a）大鼠视前区去甲肾上腺素的释放受突触前阿片受体调节；（b）视前区去甲肾上腺素释放的阿片控制变化与成年雌性大鼠的无排卵状况有关，这些成年雌性大鼠在新生期曾接触过雄激素。这些实验支持了以下假说，即视前区的阿片-去甲肾上腺素能相互作用是调节促性腺激素分泌的神经机制中的一个重要组成部分。
