Kovács G L, Telegdy G
Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary.
Brain Res Bull. 1988 Jun;20(6):893-5. doi: 10.1016/0361-9230(88)90107-4.
Oxytocin, a hypothalamo-neurohypophyseal neuropeptide was found to attenuate the development of tolerance to the analgesic action of morphine, heroin, beta-endorphin or D-Pro2-Met5-enkephalinamide. The effect of oxytocin on morphine tolerance was prevented by N alpha-acetyl-(2-0-methyltyrosine)-oxytocin or penicillamine1-(2-0-methyltyrosine)-lysine8-vasopressin, which are antagonists of oxytocin receptors. Oxytocin dose-dependently attenuated various signs of precipitated morphine withdrawal (e.g., stereotyped jumpings, hypothermia, body weight loss). The neuropeptide diminished intravenous self-administration of heroin in heroin-tolerant rats. It is concluded that brain oxytocin interferes with adaptive components of experimental drug addiction.
催产素是一种下丘脑 - 神经垂体神经肽，已发现它能减弱对吗啡、海洛因、β - 内啡肽或D - 脯氨酸2 - 蛋氨酸5 - 脑啡肽酰胺镇痛作用的耐受性发展。Nα - 乙酰 - （2 - O - 甲基酪氨酸） - 催产素或青霉胺1 - （2 - O - 甲基酪氨酸） - 赖氨酸8 - 加压素是催产素受体拮抗剂，它们可阻止催产素对吗啡耐受性的影响。催产素剂量依赖性地减弱了各种吗啡戒断症状（如刻板跳跃、体温过低、体重减轻）。该神经肽减少了海洛因耐受大鼠静脉注射海洛因的自我给药量。得出的结论是，脑内催产素会干扰实验性药物成瘾的适应性成分。
