西格玛-1受体拮抗剂氟哌啶醇可减弱巨噬细胞中由谷胱甘肽和莫利昔明诱导的钙反应。
Sigma-1 receptor antagonist haloperidol attenuates Ca responses induced by glutoxim and molixan in macrophages.
作者信息
Krutetskaya Z I, Milenina L S, Naumova A A, Butov S N, Antonov V G, Nozdrachev A D
机构信息
St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia.
出版信息
Dokl Biochem Biophys. 2017 Jan;472(1):74-76. doi: 10.1134/S1607672917010227. Epub 2017 Apr 19.
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca concentration increase in macrophages.
使用Fura-2AM显微荧光测定法，我们首次表明，σ-1受体拮抗剂、抗精神病药物氟哌啶醇可显著抑制谷胱甘肽和莫利昔明诱导的腹膜巨噬细胞中的钙反应。这些结果表明，σ-1受体可能参与了由谷胱甘肽或莫利昔明诱导并导致巨噬细胞内钙浓度升高的信号级联反应。
Zotero 插件