Beserra Milena Pontes Portela, De Oliveira Cristiani Lopes Capistrano Gonçalves, Portela Mileyde Ponte, Lopes Marcos Venícios de Oliveira, Fonteles Marta Maria de França
Research Laboratory in Clinical Pharmacy and Translational. Pharmacy Department. Federal University of Ceará. Brazil.
Nutr Hosp. 2017 Mar 30;34(2):257-263. doi: 10.20960/nh.486.
This study aimed to improve knowledge about drug administration through enteral feeding tubes (EFTs) in order to minimize efficacy and safety problems.
The study was performed in a public secondary care hospital with level II accreditation by the National Accreditation Organization (Organização Nacional de Acreditação ONA), in Fortaleza, Ceará, north-eastern Brazil.
One hundred and eight oral solid medications that could be administered through EFTs and were not available in liquid forms were evaluated via transformation of their solid dosage forms into liquid forms. Dispersion times and conditions were assessed to determine which medications should be crushed. We compared the use of dispensers and syringes and their connections to enteral feeding tubes and intravenous devices. Medications whose dispersion occurred within 20 minutes and could be visually perceived and whose content could be expelled without occluding the oral syringe were considered "satisfactory".
The dispersion was "satisfactory" in 82 (75.9%) of the medications; they were classified as capable of being dispersed in water in the oral syringe for further administration via EFTs without the need for crushing. Use the dispenser instead of the syringe for drug administration was safer because the dispenser apparatus did not fit into equipment for intravenous drug administration.
本研究旨在增进对通过肠内喂养管(EFT)给药的了解,以尽量减少疗效和安全问题。
该研究在巴西东北部塞阿拉州福塔莱萨市一家获得国家认证组织(国家认证组织,ONA)二级认证的公立二级护理医院进行。
对108种可通过EFT给药且无液体制剂的口服固体药物进行了评估,将其固体剂型转化为液体制剂。评估分散时间和条件,以确定哪些药物应碾碎。我们比较了分配器和注射器的使用及其与肠内喂养管和静脉装置的连接。分散在20分钟内发生、可目视观察到且内容物可在不堵塞口服注射器的情况下排出的药物被认为“令人满意"。
82种(75.9%)药物的分散情况“令人满意”;它们被归类为能够在口服注射器中分散于水中,以便通过EFT进一步给药,无需碾碎。使用分配器而非注射器给药更安全,因为分配器装置无法适配静脉给药设备。