重复游泳应激与离体大鼠起搏器对去甲肾上腺素和异丙肾上腺素变时作用的反应性：肾上腺皮质激素的作用

Repeated swimming stress and responsiveness of the isolated rat pacemaker to the chronotropic effect of noradrenaline and isoprenaline: role of adrenal corticosteroids.

Spadari R C, De Moraes S

Department of Physiology and Biophysics, Faculty of Medical Sciences, Universidade Estadual de Campinas, São Paulo, Brazil.

Gen Pharmacol. 1988;19(4):553-7. doi: 10.1016/0306-3623(88)90163-2.

Abstract

Repeated swimming stress (three daily sessions) resulted in an increased plasma corticosterone level and subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline. 2. Repeated swimming stress was found to decrease the affinity of beta 1-adrenoreceptors for metoprolol. 3. Bilateral adrenalectomy performed 2 days before repeated swimming stress abolished the development of pacemaker subsensitivity to noradrenaline and isoprenaline and the decrease in beta 1-adrenoreceptors affinity for metoprolol. 4. It is concluded that adrenal corticosteroids, at least partially, mediate the swimming stress-induced subsensitivity of the isolated rat pacemaker to noradrenaline and isoprenaline.

摘要

重复游泳应激（每日三次）导致大鼠血浆皮质酮水平升高，且离体大鼠心脏起搏器对去甲肾上腺素和异丙肾上腺素的敏感性降低。2. 发现重复游泳应激会降低β1 - 肾上腺素能受体对美托洛尔的亲和力。3. 在重复游泳应激前两天进行双侧肾上腺切除术，可消除心脏起搏器对去甲肾上腺素和异丙肾上腺素敏感性降低以及β1 - 肾上腺素能受体对美托洛尔亲和力下降的现象。4. 得出结论：肾上腺皮质类固醇至少部分介导了游泳应激诱导的离体大鼠心脏起搏器对去甲肾上腺素和异丙肾上腺素的敏感性降低。