Nuovo G J
Department of Microbiology, Columbia University, New York, New York 10032.
Gynecol Oncol. 1988 Sep;31(1):176-83. doi: 10.1016/0090-8258(88)90290-9.
Genital condyloma and intraepithelial neoplasia secondary to Human Papillomavirus (HPV) infection are characterized by perinuclear halos and marked nuclear atypia (koilocytotic atypia) on cytologic and histologic examination. However, at times the histologic findings, including the degree of nuclear atypia, may be suggestive but not absolutely diagnostic of an HPV related neoplasm. HPV DNA sequences were detected in 63 and 56% of colposcopically visible vaginal and cervical lesions, respectively, that were diagnosed as condyloma or intraepithelial neoplasia. HPV DNA sequences were detected in 14 and 47% of vaginal and cervical lesions, respectively, that did not fulfill the histologic criteria of condyloma or intraepithelial neoplasia (i.e., "nondiagnostic"). When examining cervices from patients with no visible lesion and no recent history of an abnormal pap smear, 5.5% had detectable HPV DNA sequences. The histologic findings in this group were equivalent to the virus-negative cases and similar to the "nondiagnostic" cervical lesions. These findings suggest that the detection rate of HPV DNA in "nondiagnostic" tissues is dependent on the site and presence or absence of a visible lesion. The rate is similar in cervical lesions regardless of the histologic findings whereas it is less in vaginal lesions when the histologic criteria of condyloma or intraepithelial neoplasia are not detected.
人乳头瘤病毒（HPV）感染继发的生殖器湿疣和上皮内瘤变，在细胞学和组织学检查中表现为核周晕及明显的核异型性（挖空细胞异型性）。然而，有时组织学表现，包括核异型性程度，可能提示但不能绝对诊断为HPV相关肿瘤。在经阴道镜检查可见的分别诊断为湿疣或上皮内瘤变的阴道和宫颈病变中，HPV DNA序列检测率分别为63%和56%。在未符合湿疣或上皮内瘤变组织学标准（即“无法诊断”）的阴道和宫颈病变中，HPV DNA序列检测率分别为14%和47%。在检查无可见病变且近期巴氏涂片无异常病史患者的宫颈时，5.5%检测到了HPV DNA序列。该组的组织学表现与病毒阴性病例相当，且与“无法诊断”的宫颈病变相似。这些发现表明，“无法诊断”组织中HPV DNA的检测率取决于部位以及是否存在可见病变。无论组织学表现如何，宫颈病变中的检测率相似；而当未检测到湿疣或上皮内瘤变的组织学标准时，阴道病变中的检测率较低。
