McAfee J G, Thomas F D, Subramanian G, Roskopf M, Hellwig B
Department of Radiology, SUNY Health Science Center, Syracuse.
J Nucl Med. 1988 Sep;29(9):1577-81.
The efficacy of different radiodiagnostic agents for demonstrating the decline in renal function from cyclosporine (CyA) nephrotoxicity was assessed in rats receiving a standard dose of the drug for 2 wk, compared with control rats. The agents included [99mTc]DTPA, [131I]hippuran, [111In]lysozyme, [99mTc]glucoheptonate (GHA), [99mTc]dimercaptosuccinate (DMS) and [111In]aminated dextran (amdex). A small dose of [99mTc]- or [111In]DTPA was administered simultaneously to normalize the results for variations in drug response from one animal to another. There were statistically significant differences in the detectability of the renal functional impairment by plasma clearance, early and 2-hr renal uptake among the different agents. However, none was clearly superior to DTPA. This conclusion is consistent with previous studies which showed a parallel decline in glomerular filtration rate (GFR) and effective renal plasma flow in acute CyA toxicity probably due primarily to vasoconstriction.
在接受标准剂量环孢素（CyA）2周的大鼠中，评估了不同放射性诊断剂用于显示CyA肾毒性导致的肾功能下降的效果，并与对照大鼠进行比较。这些试剂包括[99mTc]二乙三胺五乙酸（DTPA）、[131I]马尿酸钠、[111In]溶菌酶、[99mTc]葡庚糖酸盐（GHA）、[99mTc]二巯基丁二酸（DMS）和[111In]氨基葡聚糖（amdex）。同时给予小剂量的[99mTc]-或[111In]DTPA，以标准化不同动物之间药物反应差异的结果。不同试剂在通过血浆清除率、早期和2小时肾脏摄取来检测肾功能损害方面存在统计学显著差异。然而，没有一种试剂明显优于DTPA。这一结论与先前的研究一致，先前研究表明急性CyA毒性时肾小球滤过率（GFR）和有效肾血浆流量平行下降，这可能主要是由于血管收缩所致。
