脂肪细胞肥大-增生平衡有助于减肥手术后体重减轻。
Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.
作者信息
Muir Lindsey A, Baker Nicki A, Washabaugh Alexandra R, Neeley Christopher K, Flesher Carmen G, DelProposto Jennifer B, Geletka Lynn M, Ghaferi Amir A, Finks Jonathan F, Singer Kanakadurga, Varban Oliver A, Lumeng Carey N, O'Rourke Robert W
机构信息
a Department of Pediatrics and Communicable Diseases , University of Michigan Medical School , Ann Arbor , MI , USA.
e Graduate Program in Immunology , University of Michigan Medical School , Ann Arbor , MI , USA.
出版信息
Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.
Abstract
Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects. Decreased adipose tissue preadipocyte frequency was associated with less weight loss in women but not men. These data suggest that phenotypic features of adipose tissue remodeling may predict responses to weight loss interventions.
摘要
体重减轻反应的预测因素尚未明确界定。我们假设，与重塑相关的脂肪组织表型特征会与减肥手术的体重减轻反应相关。对减肥手术期间从患者身上采集的内脏和皮下脂肪组织进行了流式细胞术、免疫组织化学和定量逆转录聚合酶链反应研究，结果与体重减轻结果相关。年龄、男性性别和2型糖尿病诊断与体重减轻较少有关。糖尿病患者内脏脂肪组织中的脂肪细胞大小增加，前脂肪细胞频率降低。脂肪组织前脂肪细胞频率降低与女性体重减轻较少有关，但与男性无关。这些数据表明，脂肪组织重塑的表型特征可能预测对体重减轻干预的反应。
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