Iyengar Prasanna Vasudevan
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Int J Mol Sci. 2017 Apr 20;18(4):877. doi: 10.3390/ijms18040877.
The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated.
转化生长因子-β（TGF-β）信号通路在正常细胞和癌前细胞中具有肿瘤抑制作用，但在晚期癌细胞中却促进肿瘤发生。该信号通路的组成部分受到泛素修饰酶的严格调控，并且经常观察到这些酶的异常会导致该信号通路失调，从而引发诸如骨骼疾病、癌症和转移等疾病。这些酶及其对应物越来越多地被作为可成药靶点进行测试，因此需要对这些酶有更深入的了解。本综述总结了特定泛素修饰酶在TGF-β信号通路中的作用及其调控方式。
