Broecker Justine S, Khoshnam Nasim, Thompson Laura, Anis Shady, Kamal Nora, Gillespie Scott, Kantarovich Diana, Metry Diana, Mills Mary Pate, Drummey Rachel, Williams Brianna, Shehata Bahig M
a Emory University School of Medicine , Atlanta , Georgia , USA.
b Department of Pathology , Cairo University , Giza , Egypt.
Fetal Pediatr Pathol. 2017 Apr;36(2):139-148. doi: 10.1080/15513815.2017.1290724. Epub 2017 Mar 2.
Benign breast masses are uncommon but are becoming more recognized among the pediatric population. Malignant breast lesions are very rare. The aim of our study was to review and compare the demographics, clinical presentation, treatment, and outcomes of breast lesions, including primary malignancies, and to discuss theories that may explain why there is an increased rate of breast cancers diagnosed at a younger age in the Egyptian population. A total of 1031 cases were reviewed. Comparisons were made between the Egyptian (n = 846) and US (n = 185) cohorts. There were 30 (3.5%) malignant tumors in the Egyptian group with 17 (2%) deaths versus 3 (1.6%) malignant tumors in the US group with 2 (1%) deaths (p = 0.247). The relative risk of breast cancer in the Egyptian group was 2.16 (95% confidence interval (CI): 0.67-7.01) compared with the US group. The trend for increased risk of breast cancer in Egypt may be due to delayed diagnosis because of decreased awareness.
良性乳腺肿块并不常见，但在儿科人群中越来越受到关注。恶性乳腺病变非常罕见。我们研究的目的是回顾和比较乳腺病变（包括原发性恶性肿瘤）的人口统计学、临床表现、治疗和结果，并讨论可能解释为什么埃及人群中乳腺癌诊断年龄越来越小的理论。总共回顾了1031例病例。对埃及队列（n = 846）和美国队列（n = 185）进行了比较。埃及组有30例（3.5%）恶性肿瘤，17例（2%）死亡；而美国组有3例（1.6%）恶性肿瘤，2例（1%）死亡（p = 0.247）。与美国组相比，埃及组乳腺癌的相对风险为2.16（95%置信区间（CI）：0.67 - 7.01）。埃及乳腺癌风险增加的趋势可能是由于意识下降导致诊断延迟。
