Alkagiet Stelina, Tziomalos Konstantinos
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Biomol Concepts. 2017 May 24;8(2):119-123. doi: 10.1515/bmc-2017-0001.
Vascular calcification represents the deposition of calcium phosphate salts in the tunica media of the vascular wall. It occurs during aging but is accelerated and pronounced in patients with diabetes mellitus, chronic kidney disease (CKD) and established cardiovascular disease. Due to the loss of elasticity of the vessel wall, vascular calcification might result in left ventricular hypertrophy and compromise coronary perfusion. Accordingly, several studies showed that vascular calcification is associated with increased risk for cardiovascular morbidity and mortality. Accumulating data suggest that microRNAs (miRs) play an important role in vascular calcification. A variety of miRs have been implicated in the development of vascular calcification, whereas others appear to play a protective role. Accordingly, miRs might represent promising targets for the prevention of vascular calcification and its adverse cardiovascular sequelae. However, given the complexity of regulation of this process and the multitude of miRs involved, more research is needed to identify the optimal candidate miRs for targeting.
血管钙化是指磷酸钙盐在血管壁中层的沉积。它在衰老过程中发生，但在糖尿病、慢性肾脏病（CKD）和已确诊的心血管疾病患者中会加速且更为明显。由于血管壁弹性丧失，血管钙化可能导致左心室肥厚并损害冠状动脉灌注。因此，多项研究表明血管钙化与心血管疾病发病率和死亡率增加相关。越来越多的数据表明，微小RNA（miRs）在血管钙化中起重要作用。多种miRs与血管钙化的发生有关，而其他一些miRs似乎起到保护作用。因此，miRs可能是预防血管钙化及其不良心血管后果的有前景的靶点。然而，鉴于这一过程调控的复杂性以及涉及的miRs众多，需要更多研究来确定最佳的靶向候选miRs。
