Cryosurgical and thermal monitoring system for management of malignancy.

A comprehensive evaluation of the major aspects of cryosurgery has been explored in this preliminary study. A thermal monitoring system has been used concomitantly with cryosurgery, and characteristic freezing pattern differences between normal and malignant tissue have been demonstrated. Morphologic examination of the sections from the control and experimental animals subjected to cryosurgery has been valuable to demonstrate consistent tissue damage. This study has also shown the feasibility of implementing a thermodynamic mathematical model to establish the basis for clinical application of cryosurgery on a more rational therapeutic basis.