González-Jiménez Emilio, Schmidt-RioValle Jacqueline, Sinausía Laura, Perona Javier S
1 Department of Nursing, University of Granada, Granada, Spain.
2 Instituto de la Grasa-CSIC, Campus Universidad Pablo de Olavide, Seville, Spain.
Biol Res Nurs. 2017 Jul;19(4):419-427. doi: 10.1177/1099800417705464. Epub 2017 Apr 21.
Breastfeeding duration has been associated with less low-grade inflammation in healthy adolescents, but there is scarce information regarding obese subjects. This study aimed to evaluate whether exclusive breastfeeding is related to serum concentrations of inflammatory markers in a population of Spanish adolescents.
A cross-sectional study was performed on 1,001 adolescents (13.2 ± 1.2 years) randomly recruited from schools in southeast Spain. Data on breastfeeding duration were collected via a parental questionnaire. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were determined by enzyme-linked immunosorbent assay. C-reactive protein (CRP) was determined by solid-phase chemiluminescent immunometric assay.
Nonadjusted and adjusted multivariate correlation analyses confirmed a strong association ( p < .001, 95% confidence interval) between the three markers of inflammation and exclusive breastfeeding duration. No significant differences were observed for IL-6, TNF-α, and CRP serum concentrations among normal weight, overweight, and obese adolescents, except for IL-6 between normal weight and obese subjects. Likewise, no significant association was found between these markers of inflammation and body mass index (BMI) z-score.
We found a possible association between inflammatory markers and exclusive breastfeeding duration in adolescents, regardless of their BMI. This finding suggests that increased body weight or obesity might not mediate the association between breastfeeding and inflammation. These results contribute to the understanding of the relationship between breastfeeding and inflammatory markers in adolescents.
母乳喂养时间与健康青少年较低程度的炎症相关，但关于肥胖青少年的相关信息较少。本研究旨在评估纯母乳喂养是否与西班牙青少年群体中炎症标志物的血清浓度有关。
对从西班牙东南部学校随机招募的1001名青少年（13.2±1.2岁）进行了一项横断面研究。通过家长问卷收集母乳喂养时间的数据。采用酶联免疫吸附测定法测定白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。采用固相化学发光免疫分析法测定C反应蛋白（CRP）。
未经调整和调整后的多变量相关分析证实，三种炎症标志物与纯母乳喂养时间之间存在强关联（p<.001，95%置信区间）。在正常体重、超重和肥胖青少年中，IL-6、TNF-α和CRP血清浓度未观察到显著差异，但正常体重和肥胖受试者之间的IL-6除外。同样，这些炎症标志物与体重指数（BMI）z评分之间未发现显著关联。
我们发现青少年炎症标志物与纯母乳喂养时间之间可能存在关联，无论其BMI如何。这一发现表明，体重增加或肥胖可能不会介导母乳喂养与炎症之间的关联。这些结果有助于理解青少年母乳喂养与炎症标志物之间的关系。
