阿尔茨海默病中的血浆神经丝轻链水平

Plasma neurofilament light chain levels in Alzheimer's disease.

作者信息

Zhou Wenjun, Zhang Jie, Ye Fanlong, Xu Guangzheng, Su Hang, Su Yindan, Zhang Xiangyang

机构信息

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Neurosci Lett. 2017 May 22;650:60-64. doi: 10.1016/j.neulet.2017.04.027. Epub 2017 Apr 18.

DOI:10.1016/j.neulet.2017.04.027

PMID:28428015

Abstract

Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. Participants included 193 cognitively normal (CN), 198 amnestic mild cognitive impairment (aMCI) and 187 Alzheimer's disease (AD) individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Plasma NFL levels were examined by the Single Molecule array (Simoa) technique. Our results showed significantly increased plasma NFL levels in both AD (50.9pg/ml) and aMCI (43.0pg/ml) groups compared to CN (34.7pg/ml) group (both p<0.001), but with substantial overlap between the groups. Plasma NFL levels in AD group was also markedly increased, compared with aMCI group (p<0.001). Plasma NFL levels were positively associated with age (r=0.355, p<0.001) and negatively with global cognition (r=-0.355, p<0.001) in all subjects. Our results suggest that plasma NFL levels may not be a useful biomarker for the diagnosis of prodromal and dementia stages of AD.

摘要

血浆神经丝轻链（NFL）水平可能是神经元损伤的一个标志物。我们研究了血浆NFL是否可能是阿尔茨海默病（AD）前驱期和痴呆期的潜在生物标志物。参与者包括193名认知正常（CN）者、198名遗忘型轻度认知障碍（aMCI）者和187名阿尔茨海默病（AD）患者，他们均参与了阿尔茨海默病神经影像学倡议（ADNI）。采用单分子阵列（Simoa）技术检测血浆NFL水平。我们的结果显示，与CN组（34.7pg/ml）相比，AD组（50.9pg/ml）和aMCI组（43.0pg/ml）的血浆NFL水平均显著升高（p均<0.001），但各组之间存在大量重叠。与aMCI组相比，AD组的血浆NFL水平也显著升高（p<0.001）。在所有受试者中，血浆NFL水平与年龄呈正相关（r=0.355，p<0.001），与整体认知呈负相关（r=-0.355，p<0.001）。我们的结果表明，血浆NFL水平可能不是AD前驱期和痴呆期诊断的有用生物标志物。