Heller M, Majewski H, Crone-Münzebrock W, Knop J, Weh H J
Radiologische Klinik, Abteilung Röntgendiagnostik, Universitätskrankenhaus Eppendorf, Hamburg.
Rofo. 1988 Aug;149(2):121-8. doi: 10.1055/s-2008-1048310.
The changes in bone metastases from carcinoma of the breast induced by treatment have been analysed from their radiological appearances in a series of 58 patients and for an average period of 7.2 years. Indicators of regression are recalcification or re-ossification of primary osteolyses (46.8%), the development of marginal sclerosis round the defect (15.9%) and lack of progression over a period of 9 to 12 months (11.6%). Decreased sclerosis in primary osteosclerotic metastases (9.4%) may also be evidence of regression. Primary osteolytic/osteosclerotic metastases behave similar as osteolytic lesions. Recurrence or progress of tumour produces new metastases (39.6%), progressive osteolysis (26.6%), sclerosis (7.3%) and increased tumour size (15.4%).
通过对58例患者进行平均7.2年的随访，并根据其影像学表现，分析了乳腺癌骨转移经治疗后的变化情况。骨转移灶消退的指标包括原发病灶溶骨区重新钙化或再骨化（46.8%）、病灶周围出现边缘性硬化（15.9%）以及在9至12个月内无进展（11.6%）。原发病灶骨硬化性转移灶硬化程度降低（9.4%）也可能是消退的证据。原发病灶溶骨/骨硬化性转移灶与溶骨性病变表现相似。肿瘤复发或进展会产生新的转移灶（39.6%）、进行性溶骨（26.6%）、硬化（7.3%）以及肿瘤体积增大（15.4%）。
