Arutyunyan A V, Zaloznyaya I V, Kerkeshko G O, Milyutina Yu P, Korenevskii A V
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia.
Bull Exp Biol Med. 2017 Apr;162(6):738-740. doi: 10.1007/s10517-017-3701-6. Epub 2017 Apr 20.
Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.
研究了产前高同型半胱氨酸血症对雌性大鼠下丘脑发情周期调节的影响。在暴露于产前高同型半胱氨酸血症的成年大鼠中，发现负责促性腺激素释放激素排卵前激增形成的下丘脑区域儿茶酚胺含量发生变化：视前内侧区去甲肾上腺素水平降低，弓状核正中隆起多巴胺浓度增加。褪黑素的给药减弱了观察到的变化，这可能与其抗氧化特性所决定的神经保护作用有关。
