Polonskaya Ya V, Kashtanova E V, Murashov I S, Volkov A M, Kurguzov A V, Chernyavsky A M, Ragino Yu I
Research Institute of Internal and Preventive Medicine, Novosibirsk, Russia.
E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Novosibirsk, Russia.
Bull Exp Biol Med. 2017 Apr;162(6):726-729. doi: 10.1007/s10517-017-3698-x. Epub 2017 Apr 21.
We studied associations of osteocalcin, osteoprotegerin, and calcitonin with markers of inflammation in atherosclerotic plaques in coronary arteries and assessed the influence of these biomolecules on calcification of atherosclerotic plaques. The initial stage of calcification of atherosclerotic plaques is characterized by activation of inflammatory processes, which is seen from increased levels of proinflammatory biomarkers (IL-6, IL 8, TNF-α, and IL-1β). Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin. The exception is osteocalcin, its concentration significantly increased during calcification. The results suggest that severe vascular calcification can be regarded as non-specific marker of atherosclerosis. Instability of atherosclerotic plaques is associated with higher level of calcification.
我们研究了骨钙素、骨保护素和降钙素与冠状动脉粥样硬化斑块中炎症标志物的关联，并评估了这些生物分子对动脉粥样硬化斑块钙化的影响。动脉粥样硬化斑块钙化的初始阶段以炎症过程的激活为特征，这可从促炎生物标志物（IL-6、IL-8、TNF-α和IL-1β）水平的升高看出。动脉粥样硬化斑块的进行性钙化伴随着降钙素和骨保护素的少量积累。例外的是骨钙素，其浓度在钙化过程中显著增加。结果表明，严重的血管钙化可被视为动脉粥样硬化的非特异性标志物。动脉粥样硬化斑块的不稳定性与较高的钙化水平相关。
