Amaya Toru, Osafune Yuma, Maegawa Yusuke, Hirao Toshikazu
Graduate School of Engineering, Department of Applied Chemistry, Osaka University, Yamada-oka, Suita, Osaka, 565-0871, Japan.
The Institute of Scientific and Industrial Research, Osaka University, Mihoga-oka, Ibaraki, Osaka, 567-0047, Japan.
Chem Asian J. 2017 Jun 19;12(12):1301-1304. doi: 10.1002/asia.201700470. Epub 2017 Jun 1.
Intermolecular oxidative cross-coupling of two different enolates is one of the most useful reactions to synthesize unsymmetrical 1,4-dicarbonyl compounds. In this study, the oxovanadium(V)-induced intermolecular oxidative cross-coupling of enolates afforded unsymmetrical 1,4-dicarbonyl compounds. Various boron and silyl enolates underwent the formation of ketone-ester, ester-ketone, ester-ester, amide-ketone and amide-ester coupling products . These results clearly show the versatility of the present oxidative cross-coupling protocol.
两种不同烯醇盐的分子间氧化交叉偶联是合成不对称1,4 - 二羰基化合物最有用的反应之一。在本研究中，氧钒（V）诱导的烯醇盐分子间氧化交叉偶联反应生成了不对称1,4 - 二羰基化合物。各种硼烯醇盐和硅烯醇盐都能生成酮 - 酯、酯 - 酮、酯 - 酯、酰胺 - 酮和酰胺 - 酯偶联产物。这些结果清楚地表明了当前氧化交叉偶联方法的通用性。
