Whitaker-Dowling P, Youngner J S
Department of Microbiology, Biochemistry and Molecular Biology, University of Pittsburgh School of Medicine, PA 15261.
Virus Res. 1988 May;10(2-3):215-24. doi: 10.1016/0168-1702(88)90017-2.
Coinfection with vaccinia virus increases the growth of vesicular stomatitis virus (VSV) in mouse L cells by 10- to 20-fold. Although vaccinia has no significant effect on RNA synthesis by VSV, VSV protein synthesis is dramatically stimulated by double infection. The enhancement of VSV growth is correlated with the ability of vaccinia to inhibit the VSV-mediated damage to the host translational machinery. Coinfection with vaccinia fails to stimulate the growth of a VSV mutant which is deficient in its ability to shut off protein synthesis during infection.
痘苗病毒共感染可使水泡性口炎病毒（VSV）在小鼠L细胞中的生长增加10至20倍。尽管痘苗对VSV的RNA合成没有显著影响，但双重感染可显著刺激VSV蛋白合成。VSV生长的增强与痘苗抑制VSV介导的对宿主翻译机制损伤的能力相关。痘苗病毒共感染不能刺激一种在感染期间关闭蛋白质合成能力存在缺陷的VSV突变体的生长。
