Pınar Neslihan, Soylu Karapınar Oya, Özcan Oğuzhan, Özgür Tümay, Bayraktar Suphi
Department of Medical Pharmacology, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
Department of Obstetrics and Gynaecology, School of Medicine, Mustafa Kemal University, Hatay, Turkey, 31100.
Fundam Clin Pharmacol. 2017 Oct;31(5):506-512. doi: 10.1111/fcp.12293. Epub 2017 May 30.
To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.
通过评估生化和组织病理学参数，研究α-硫辛酸（ALA）在实验性大鼠子宫内膜异位症模型治疗中的抗氧化和抗炎作用。通过腹腔内植入自体子宫内膜组织诱导实验性子宫内膜异位症。将大鼠随机分为两组，每组8只。第一组腹腔注射ALA 100 mg/kg/天，共14天。第二组腹腔注射相同剂量和相同时间的生理盐水溶液。在治疗前后测量两组的子宫内膜植入物体积。测量腹腔液中的肿瘤坏死因子α（TNF-α）。评估血清中的总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）。对植入物进行组织病理学评估。与对照组相比，ALA组的血清TOS和OSI水平、子宫内膜植入物体积、血清和腹腔液中的TNF-α水平以及组织病理学评分均显著降低（P < 0.05）。由于其抗氧化和抗炎作用，α-硫辛酸可能在子宫内膜异位症的治疗中具有治疗潜力。
