Trulson M E, Ulissey M J
Department of Anatomy, College of Medicine, Texas A&M University.
Acta Anat (Basel). 1988;132(3):177-81. doi: 10.1159/000146571.
Forebrain arterioles were analyzed histochemically to determine the effects of an acute administration of ethanol on key enzymes of aerobic and anaerobic metabolism as well as on the hexose monophosphate shunt in rats. The enzymes were glucose 6-phosphate dehydrogenase, cytochrome oxidase, lactate dehydrogenase, beta-hydroxybutyrate dehydrogenase, and isocitrate dehydrogenase. All enzymes were quantified under two conditions: 1 h and 2 days after ethanol administration. Significant changes were noted in four of the five enzymes measured after 1 h and in all five enzymes when measured 2 days after ethanol administration. Our data suggest that ethanol may cause impaired metabolism in the forebrain microvasculature, which, in turn, may account for some of the characteristic behavioral effects of acute ethanol administration.
对大鼠前脑小动脉进行组织化学分析，以确定急性给予乙醇对有氧和无氧代谢关键酶以及磷酸己糖支路的影响。这些酶包括葡萄糖6 - 磷酸脱氢酶、细胞色素氧化酶、乳酸脱氢酶、β - 羟基丁酸脱氢酶和异柠檬酸脱氢酶。所有酶在两种条件下进行定量：乙醇给药后1小时和2天。乙醇给药后1小时测定的五种酶中有四种以及给药后2天测定的所有五种酶均出现显著变化。我们的数据表明，乙醇可能导致前脑微血管代谢受损，这反过来可能解释急性乙醇给药的一些特征性行为效应。
