先天性低丙种球蛋白血症患者持续性脑炎使用脑室内注射丙种球蛋白和α干扰素治疗失败。
Failure of intraventricular gammaglobulin and alpha interferon for persistent encephalitis in congenital hypogammaglobulinaemia.
作者信息
Roberton D M, Jack I, Joshi W, Law F, Hosking C S
机构信息
Department of Immunology, Royal Children's Hospital, Melbourne, Victoria, Australia.
出版信息
Arch Dis Child. 1988 Aug;63(8):948-52. doi: 10.1136/adc.63.8.948.
A boy with congenital hypogammaglobulinaemia died at the age of 12 years after a viral meningoencephalitis of two and a half years duration due to an untypable picornavirus. He had received intravenous immunoglobulin every four weeks from the time of the start of immunoglobulin replacement treatment at the age of 3 years. The encephalitis did not respond to high dose intravenous gammaglobulin (2500 g during 22 months). The virus could not be isolated during the administration of intraventricular immunoglobulin (38.15 g) and intraventricular recombinant alpha interferon (121 X 10(6) units), but recurred rapidly each time intraventricular treatment was stopped. Further modes of treatment are still required for prevention and treatment of this disorder.
一名患有先天性低丙种球蛋白血症的男孩，在患持续两年半的病毒性脑膜脑炎后，于12岁时死亡，该病毒性脑膜脑炎由一种无法分型的微小核糖核酸病毒引起。自3岁开始免疫球蛋白替代治疗起，他每四周接受一次静脉注射免疫球蛋白。高剂量静脉注射丙种球蛋白（22个月内共2500克）对该脑炎无效。在脑室内注射免疫球蛋白（38.15克）和脑室内注射重组α干扰素（121×10⁶单位）期间，病毒未能分离出来，但每次停止脑室内治疗后，病毒都会迅速复发。预防和治疗这种疾病仍需要进一步的治疗方式。
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