小儿患者单次坐骨神经阻滞联合连续股神经阻滞后的布比卡因血药浓度：一项前瞻性观察研究。

Blood Bupivacaine Concentrations After a Combined Single-Shot Sciatic Block and a Continuous Femoral Nerve Block in Pediatric Patients: A Prospective Observational Study.

作者信息

Suresh Santhanam, De Oliveira Gildasio S

机构信息

From the *Department of Anesthesiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; and †Department of Anesthesiology, Northwestern University, Chicago, Illinois.

出版信息

Anesth Analg. 2017 May;124(5):1591-1593. doi: 10.1213/ANE.0000000000001531.

DOI:10.1213/ANE.0000000000001531

PMID:28431423

Abstract

We evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours. The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.

摘要

我们评估了前交叉韧带修复术后接受单次坐骨神经阻滞和连续股神经阻滞的儿童的血液布比卡因浓度。在0、5、15、30、60和120分钟以及4、24和48小时对干血斑样本进行布比卡因水平分析。在4小时评估点，最高的99%置信区间上限为135 ng/mL。在所有采样时间，99%置信区间均低于潜在中毒水平（1500 ng/mL）。接受单次坐骨神经阻滞和连续股神经阻滞的儿科患者发生局部麻醉药中毒的风险非常低。