泰国东北部235名个体中杀伤细胞免疫球蛋白样受体（KIR）和人类白细胞抗原（HLA）配体的遗传学研究。
Genetic study of KIR and HLA ligands in 235 individuals from Northeastern Thailand.
作者信息
Chaisri Suwit, Leelayuwat Chanvit, Romphruk Amornrat
机构信息
Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani 12121, Thailand; The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Clinical Immunology and Transfusion Sciences, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
Hum Immunol. 2017 May-Jun;78(5-6):395-396. doi: 10.1016/j.humimm.2017.04.002. Epub 2017 Apr 18.
The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP) method. The Hardy-Weinberg Equilibrium (HWE) was used to verify genotyping method for dimorphic KIR and HLA. They were in HWE (p>0.05). KIR and HLA ligands frequencies, genotypes, haplotypes and linkage disequilibrium (LD) were presented. The genetic data are available in allele Frequencies Net Database.
采用序列特异性引物聚合酶链反应（PCR-SSP）方法，对235名泰国东北部无血缘关系的健康供者（NETs）的17种杀伤细胞免疫球蛋白样受体（KIR）和人类白细胞抗原（HLA）配体（HLA-C1、C2、Bw4、A11）的多样性进行了研究。采用哈迪-温伯格平衡（HWE）来验证双态KIR和HLA的基因分型方法。它们符合哈迪-温伯格平衡（p>0.05）。呈现了KIR和HLA配体的频率、基因型、单倍型及连锁不平衡（LD）情况。遗传数据可在等位基因频率网络数据库中获取。
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