Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Woman and Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Sci Rep. 2017 Apr 21;7(1):1031. doi: 10.1038/s41598-017-01068-w.
Estimates of trends in birth weight may be useful in evaluating population health. We aimed to determine whether temporal changes in birth weight have occurred amongst 2.3 million neonates born in Guangzhou, China, during 2001-2015 and investigate the socioeconomic determinants of any changes. Trends in mean birth weight and annualized changes with the associated 95% confidence intervals (CIs) in the incidence of small for gestational age (SGA) and large for gestational age (LGA), defined as birth weight <10 or >90 centile respectively for gestational age and sex, were examined using linear and Poisson regression models. We found that mean birth weight declined by 1.07 grams/year from 2001 to 2015. After adjustment for gestational length, the decline in birth weight was attenuated (0.37 grams/year). The incidence of both SGA and LGA significantly decreased during the study period (annual decrease of 1.6% [95% CI, 1.5% to 1.7%] for SGA, 1.6% [95% CI, 1.5% to 1.8%] for LGA). We found a narrowing of disparities in SGA and LGA incidence across different maternal educational levels and residence location. Our results demonstrate that there has been an increase in the proportion of neonates born in the healthy birth weight range in Guangzhou.
估计出生体重的趋势可能有助于评估人口健康状况。我们旨在确定在中国广州，2001-2015 年间出生的 230 万新生儿的出生体重是否发生了变化，并调查任何变化的社会经济决定因素。使用线性和泊松回归模型检查了平均出生体重的趋势以及小胎龄儿（SGA）和大胎龄儿（LGA）发生率的年化变化，以及各自的 95%置信区间（CI）。小胎龄儿和大胎龄儿分别定义为出生体重低于相应胎龄和性别的第 10 百分位数或高于第 90 百分位数。我们发现，2001 年至 2015 年，平均出生体重每年下降 1.07 克。调整胎龄后，出生体重的下降幅度减弱（每年 0.37 克）。在此研究期间，SGA 和 LGA 的发生率均显著下降（SGA 的年下降率为 1.6%[95%CI，1.5%至 1.7%]，LGA 的年下降率为 1.6%[95%CI，1.5%至 1.8%]）。我们发现，不同母亲教育程度和居住地的 SGA 和 LGA 发生率之间的差距正在缩小。我们的研究结果表明，在广州，出生体重处于健康范围内的新生儿比例有所增加。
