Mojica Jeffrey, Mo Bi, Ng Andrew
Jefferson Pain Center, Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, PA, 19107, USA.
Curr Pain Headache Rep. 2017 Jun;21(6):27. doi: 10.1007/s11916-017-0626-8.
Sphenopalatine ganglion (SPG) block has been used by clinicians in the treatment of a variety of headache disorders, facial pain syndromes, and other facial neuralgias. The sensory and autonomic fibers that travel through the SPG provided the scientific rationale for symptoms associated with these head and neck syndromes. Yet, despite the elucidation of this pathogenic target, the optimal method to block its pain-producing properties has not been determined. Clinicians have developed various invasive and non-invasive techniques, each of which has shown variable rates of success. We examined the available studies of sphenopalatine ganglion blockade and its efficacy in the treatment of cluster headaches, migraines, and other trigeminal autonomic cephalalgias.
Studies have demonstrated that SPG blockade and neurostimulation can provide pain relief in patients with cluster headaches, migraines, and other trigeminal autonomic cephalalgias. Patients with these conditions showed varying levels and duration of pain relief from SPG blockade. The efficacy of SPG blockade could be related to the different techniques targeting the SPG and choice of therapeutic agents. Based on current studies, SPG blockade is a safe and effective treatment for chronic headaches such as cluster headaches, migraines, and other trigeminal autonomic cephalalgias. Future studies are warranted to define the optimal image-guided technique and choice of pharmacologic agents for SPG blockade as an effective treatment for chronic headaches related to activation of the sphenopalatine ganglion.
蝶腭神经节(SPG)阻滞已被临床医生用于治疗多种头痛疾病、面部疼痛综合征及其他面部神经痛。穿过SPG的感觉和自主神经纤维为这些头颈部综合征相关症状提供了科学依据。然而,尽管已明确这一致病靶点,但阻断其产生疼痛特性的最佳方法尚未确定。临床医生已开发出各种有创和无创技术,每种技术的成功率各不相同。我们研究了关于蝶腭神经节阻滞及其在治疗丛集性头痛、偏头痛和其他三叉自主神经性头痛方面疗效的现有研究。
研究表明,SPG阻滞和神经刺激可为丛集性头痛、偏头痛和其他三叉自主神经性头痛患者缓解疼痛。患有这些疾病的患者从SPG阻滞中获得的疼痛缓解程度和持续时间各不相同。SPG阻滞的疗效可能与针对SPG的不同技术及治疗药物的选择有关。基于目前的研究,SPG阻滞是治疗慢性头痛如丛集性头痛、偏头痛和其他三叉自主神经性头痛的一种安全有效的方法。有必要开展进一步研究,以确定作为治疗与蝶腭神经节激活相关慢性头痛的有效方法,SPG阻滞的最佳影像引导技术和药物选择。