Infertility Center of St. Louis, St. Louis, Missouri.
Kato Ladies Clinic, Tokyo, Japan.
Fertil Steril. 2017 May;107(5):1232-1237. doi: 10.1016/j.fertnstert.2017.03.014. Epub 2017 Apr 19.
To study the intrinsic fertility of the human oocyte.
A large retrospective study of natural cycle single embryo transfer (ET) IVF cycles.
Private IVF clinic, university, and private hospital.
PATIENT(S): Patients were enrolled consecutively over an 8-year period in a single ET natural cycle protocol.
INTERVENTION(S): A total of 13,949 oocyte retrievals with natural IVF single ET. Software package R (version 3.2.5) was used for statistical calculations.
MAIN OUTCOME MEASURE(S): Live baby rate per oocyte according to age.
RESULT(S): A total of 14,185 natural cycle oocytes resulted in 1,913 live babies from single ET. The number of oocytes required to make one live baby in this large series varied with the age of the female partner. For those under 35, the live baby born per oocyte was 26%. For over age 42 it decreased to 1%. These results fit very robustly with a logistic function curve, which is at first steady (horizontal), followed by a linear decline after age 35 with a 10% loss every year until age 43, and then a flattening out (horizontal) by age 44.
CONCLUSION(S): The intrinsic fertility per oocyte in natural cycle is far greater than reported in hyperstimulated cycles, varying robustly from 26% to 4% with age from <35 to 42 years. The curve is relatively flat until age 34, and then declines rapidly 10% per year thereafter.
研究人类卵子的内在生育能力。
一项对自然周期单个胚胎移植（ET）IVF 周期的大型回顾性研究。
私人 IVF 诊所、大学和私人医院。
在单个 ET 自然周期方案中，连续 8 年期间招募了患者。
共进行了 13949 次自然 IVF 单个 ET 的取卵。使用 R 软件包（版本 3.2.5）进行统计计算。
根据年龄计算每个卵子的活产婴儿率。
14185 个自然周期卵母细胞经单个 ET 后产生 1913 个活产婴儿。在这个大型系列中，每个卵子需要多少个卵子才能产生一个活产婴儿，这与女性伴侣的年龄有关。对于年龄在 35 岁以下的人，每个卵子的活产婴儿比例为 26%。对于 42 岁以上的人，这个比例下降到 1%。这些结果与逻辑函数曲线非常吻合，该曲线最初是稳定的（水平），然后在 35 岁后呈线性下降，每年下降 10%，直到 43 岁，然后在 44 岁时趋于平稳（水平）。
自然周期每个卵子的内在生育能力远远高于超刺激周期报告的结果，从 35 岁以下到 42 岁，每个卵子的生育能力从 26%到 4%呈稳健变化。该曲线在 34 岁之前相对平坦，然后每年迅速下降 10%。
