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Mol Ther. 2017 May 3;25(5):1234-1247. doi: 10.1016/j.ymthe.2017.03.002. Epub 2017 Mar 22.
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Engineered T cells: the promise and challenges of cancer immunotherapy.工程化T细胞:癌症免疫疗法的前景与挑战
Nat Rev Cancer. 2016 Aug 23;16(9):566-81. doi: 10.1038/nrc.2016.97.
3
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.通过组合抗原感应电路实现T细胞的精准肿瘤识别
Cell. 2016 Feb 11;164(4):770-9. doi: 10.1016/j.cell.2016.01.011. Epub 2016 Jan 28.
4
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Front Immunol. 2014 Dec 11;5:636. doi: 10.3389/fimmu.2014.00636. eCollection 2014.
5
Chimeric antigen receptor T cells for sustained remissions in leukemia.用于白血病持续缓解的嵌合抗原受体T细胞。
N Engl J Med. 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222.
6
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia.19-28z嵌合抗原受体T细胞疗法治疗B细胞急性淋巴细胞白血病的疗效及毒性管理
Sci Transl Med. 2014 Feb 19;6(224):224ra25. doi: 10.1126/scitranslmed.3008226.
7
Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo.具有分离信号结构域的嵌合抗原受体 T 细胞在体内表现出聚焦的抗肿瘤活性,降低了毒性的潜在风险。
Cancer Immunol Res. 2013 Jul;1(1):43-53. doi: 10.1158/2326-6066.CIR-13-0008.
8
Regulation of ligands for the NKG2D activating receptor.NKG2D 激活受体配体的调节。
Annu Rev Immunol. 2013;31:413-41. doi: 10.1146/annurev-immunol-032712-095951. Epub 2013 Jan 3.
9
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.组合抗原识别与平衡信号促进了工程 T 细胞对肿瘤的选择性清除。
Nat Biotechnol. 2013 Jan;31(1):71-5. doi: 10.1038/nbt.2459. Epub 2012 Dec 16.
10
gammadelta T cells in cancer immunotherapy: current status and future prospects.γδ T 细胞在癌症免疫治疗中的应用:现状与展望。
Immunotherapy. 2009 Jul;1(4):663-78. doi: 10.2217/imt.09.27.

Sensing Bad: Are Co-stimulatory CAR-Expressing γδ T Cells Safer?

作者信息

Parihar Robin

机构信息

Section of Hematology-Oncology, Texas Children's Hospital, Baylor College of Medicine, Center for Cell and Gene Therapy, 1102 Bates Ave, Suite 1770.02, Houston, TX 77030, USA.

出版信息

Mol Ther. 2017 May 3;25(5):1064-1066. doi: 10.1016/j.ymthe.2017.04.012. Epub 2017 Apr 19.

DOI:10.1016/j.ymthe.2017.04.012
PMID:28433402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5417836/
Abstract
摘要