Yang Long, Dong Xiujuan
Department of Emergency, Cangzhou City Central Hospital Brain Campus, Xinhua West Road, Cangzhou 061000, China.
Department of Obstetrics, Cangzhou City Central Hospital, Xinhua West Road, Cangzhou 061000, China.
Environ Toxicol Pharmacol. 2017 Jun;52:177-182. doi: 10.1016/j.etap.2017.04.005. Epub 2017 Apr 13.
We aimed to evaluate the effect of natural antioxidant crocin in alleviating hemorrhagic shock (HS)-induced organ damages. HS rats were treated with crocin during resuscitation. Mortality at 12h and 24h post resuscitation was documented. HS and resuscitation induced organ injuries, as characterized by elevated wet/dry ratio, quantitative assessment ratio, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine aminotransferase, whereas rats received crocin treatment demonstrated improvements in all the above characteristics. This protective effect coincided with reduced malondialdehyde and increased glutathione in both serum and lung tissues, indicating attenuated oxidative stress in crocin-treated rats. Myeloperoxide levels in lung, kidney and liver were also reduced. Crocin can potentially be used to protect organs from HS-induced damages during resuscitation due to its anti-oxidative role.
我们旨在评估天然抗氧化剂藏红花素在减轻失血性休克（HS）诱导的器官损伤方面的作用。在复苏过程中，对HS大鼠给予藏红花素治疗。记录复苏后12小时和24小时的死亡率。HS和复苏诱导了器官损伤，其特征为湿/干比、定量评估比、血尿素氮、肌酐、天冬氨酸转氨酶和丙氨酸转氨酶升高，而接受藏红花素治疗的大鼠在上述所有特征方面均有改善。这种保护作用与血清和肺组织中丙二醛减少、谷胱甘肽增加相一致，表明藏红花素治疗的大鼠氧化应激减轻。肺、肾和肝脏中的髓过氧化物水平也降低。由于其抗氧化作用，藏红花素在复苏过程中有可能用于保护器官免受HS诱导的损伤。
