Yang Long, Dong Xiujuan
1 Department of Emergency, Cangzhou City Central Hospital Brain Campus , Cangzhou, China .
2 Department of Obstetrics, Cangzhou City Central Hospital , Cangzhou, China .
J Interferon Cytokine Res. 2017 Jul;37(7):295-302. doi: 10.1089/jir.2016.0137. Epub 2017 Apr 28.
Hemorrhagic shock (HS) is associated with an excessive activation of inflammation, contributing to multiple organ failure in numerous medical or surgical conditions. To explore the therapeutic potential of crocin, a natural compound with anti-inflammatory properties, we administered crocin to rats during resuscitation following HS induced by withdrawing blood. Compared with control animals which were sham-treated, HS-operated rats showed organ damages as manifested by enhanced markers of multiple organ dysfunctions. Crocin treatment substantially reduced these parameters in rats subjected to HS, suggesting an alleviation of tissue injuries such as in the kidney, liver, pancreas, and muscle. The activation of NF-κB (nuclear factor κB) pathway in lung tissue by HS, as shown by increased nuclear translocation of p65 and IκBα phosphorylation, was diminished by crocin treatment. The crocin administration also significantly decreased the serum levels of proinflammatory cytokine TNF-α (tumor necrosis factor-α) and interleukin (IL)-6, whereas increased the level of anti-inflammatory cytokine IL-10 in HS-operated rats. These studies indicate that crocin administration may reduce inflammation-driven tissue damage in patients with HS.
失血性休克（HS）与炎症的过度激活有关，在许多医疗或外科疾病中会导致多器官功能衰竭。为了探索具有抗炎特性的天然化合物藏红花素的治疗潜力，我们在通过放血诱导的HS复苏过程中给大鼠施用藏红花素。与假处理的对照动物相比，接受HS手术的大鼠表现出器官损伤，表现为多器官功能障碍标志物升高。藏红花素治疗显著降低了HS大鼠的这些参数，表明减轻了肾脏、肝脏、胰腺和肌肉等组织的损伤。HS诱导肺组织中NF-κB（核因子κB）途径的激活，表现为p65核转位增加和IκBα磷酸化，而藏红花素治疗减弱了这种激活。施用藏红花素还显著降低了HS手术大鼠血清促炎细胞因子TNF-α（肿瘤坏死因子-α）和白细胞介素（IL）-6的水平，而增加了抗炎细胞因子IL-10的水平。这些研究表明，施用藏红花素可能减轻HS患者炎症驱动的组织损伤。
