MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Protein Cell. 2018 Feb;9(2):145-151. doi: 10.1007/s13238-017-0409-3. Epub 2017 Apr 22.
The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.
雷帕霉素靶蛋白（mTOR）信号通路调节着不同器官或组织中的许多代谢和生理过程。mTOR 信号的失调与许多人类疾病有关，包括肥胖、糖尿病、癌症、脂肪肝疾病和神经紊乱。在这里，我们综述了近年来对 mTORC1（mTOR 复合物 1）信号如何调节肝脏脂质代谢的理解进展。
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