生长、代谢及疾病中的mTOR信号传导
mTOR Signaling in Growth, Metabolism, and Disease.
作者信息
Saxton Robert A, Sabatini David M
机构信息
Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.
Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.
出版信息
Cell. 2017 Mar 9;168(6):960-976. doi: 10.1016/j.cell.2017.02.004.
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR signaling network contributes to human disease and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.
雷帕霉素的作用机制靶点（mTOR）可根据包括营养物质和生长因子在内的环境输入来协调真核细胞的生长和代谢。在过去二十年中，广泛的研究已确立了mTOR在调节从蛋白质合成到自噬等许多基本细胞过程中的核心作用，而mTOR信号失调与癌症、糖尿病的进展以及衰老过程有关。在此，我们综述了近期在理解mTOR在哺乳动物生理学中的功能、调节及其重要性方面取得的进展。我们还强调了mTOR信号网络如何导致人类疾病，并讨论了在临床上以mTOR为治疗靶点的现状和未来前景。
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